- The question
- If a cell's commitment to death runs through one channel, can the threshold be set from outside — and set selectively?
- The instrument
- A cofactor equation mapping how hexokinase-II, Bcl-xL, and cholesterol jointly set the apoptotic threshold, expanded into six atlas layers and 22 mechanisms, plus the Gate-Jamming Score as a candidate biomarker for cancer immune evasion.
- The finding
- The model generates 24 experimentally verifiable predictions about selective toxicity from cofactor occupancy, and the CBD two-pathway component reaches 90% concordance against 70+ published papers.
- What failed
- Nothing has failed yet, and that is precisely the problem. Concordance with published literature is not validation — it is agreement with the same corpus the model was built from. None of the 24 predictions has been tested at a bench.
- Standing
- Biomedical hypothesis setAwaiting wet-lab validationUntested in vivo
Biomedical hypothesis set
VDAC1 Pharmacology Atlas
The voltage-dependent anion channel modelled as a druggable mitochondrial decision gate.
Biomedical hypothesis setAwaiting wet-lab validationUntested in vivo
24 testable predictions · 0 tested at the bench
Metrics with scope
Every number names what was measured, on what sample, and as of when.
Testable predictions
24
Derived from cofactor occupancy; none experimentally tested
As of 2026-02-16 · source
Atlas layers
6 layers · 22 mechanisms
Multi-LLM convergence portrait, literature-derived
As of 2026-02-16
CBD concordance
90%
Two-pathway model vs. 70+ published papers — agreement, not validation
As of 2026-02-12 · source
From wonder to receipt
VDAC1 Pharmacology Atlas
Wonder initiated the search. Rigor changed the answer.
Biomedical hypothesis setAwaiting wet-lab validationUntested in vivo
- 01Wonder
If a cell's commitment to its own death runs through a single gate, could that gate be reached from outside — and reached selectively?
- 02Hypothesis
If hexokinase-II, Bcl-xL, and cholesterol jointly set the apoptotic threshold, their occupancy should predict which cells can be pushed across it and which cannot.
- 03Instrument
A cofactor equation expanded into six atlas layers and 22 mechanisms, plus the Gate-Jamming Score as a candidate biomarker for immune evasion.
- 04Encounter
24 experimentally verifiable predictions, and 90% concordance for the CBD component against 70+ published papers. Concordance is agreement with the corpus the model was built from — it is not validation.
- 05Standing
Untested in vivo. Nothing here has met a bench. The predictions are the product; the evidence is outstanding.
- 06Receipt
OSF 10.17605/OSF.IO/C9RQB · vdac-pharmacology-atlas