About
Anthony J. Vasquez Sr.
Independent researcher · Temple of Two
Temple of Two started with a pattern that wouldn't let go. Three substrates. Three scales. The same fork in the road.
Faith opens the inquiry. Rigor governs the claim.
The voltage-dependent anion channel gates mitochondrial apoptosis through bistable switching — open or closed, live or die. Kuramoto oscillators synchronize through phase coupling that produces the same ±√u bifurcation structure. Transformer attention selects between competing representations under continuous input.
This research program investigates whether that recurrence is coincidence or constraint — whether binary commitment under continuous perturbation is a necessary structure wherever systems face irreversible decisions. The work is computational, the predictions are testable, and the code is open.
The VDAC Pharmacology Atlas has produced 24 experimentally verifiable hypotheses awaiting wet-lab collaboration. The CBD two-pathway model has been checked against 70+ published papers with 90% concordance — agreement with the literature, which is not the same thing as validation.
And the failures are published alongside the successes. The liminal K-SSM negative result showed that beautiful oscillator dynamics don't automatically improve language models. Constraining the hypothesis space is part of the work.
If you run assays, have a centrifuge, or just think this is the right question — reach out.
- Affiliation
- AV Family Enterprise LLC
- Focus
- Computational pharmacology, dynamical systems, AI architecture, computational phenomenology
- ORCID
- 0009-0000-6440-1506
- Contact
- info@thetempleoftwo.com
Why Temple of Two?
The name began with two substrates: biological and computational. We were asking whether living cells and artificial systems might share a grammar of threshold and commitment.
The work widened. “Two” now also names the pairs we refuse to collapse: wonder and rigor, faith and evidence, continuity and discontinuity, human and machine, experience and measurement.
The Temple is not a claim that these are identical. It is the place built to let them meet without either being erased.
Ethos
Rigor is how we honor the questions
The question may precede the evidence
Wonder is allowed to ask past what can currently be shown. It is not allowed to answer. Every question that enters the work is named as a question until an instrument says otherwise.
Every claim carries its standing
Type, lifecycle, and evidence travel with the claim wherever it renders. A shipping instrument, an untested hypothesis, and a first-person account are never displayed as the same kind of thing.
Negative results stay visible
An idea that cannot be falsified stays in the notebook. An idea that fails the test stays in the record. Constraining the hypothesis space is progress, and deleting the failure destroys it.
Collaborate
This work needs hands, not just models
- Wet-lab collaborator (VDAC assays)
- Electrophysiology (ion channel recording)
- Pharmacology reviewer
- Dynamical systems theorist
- Computational phenomenology researcher
In Memoriam
Javier “Kojak” Colon
February 21, 1964 – December 6, 2025
“We are confident, I say, and willing rather to be absent from the body, and to be present with the Lord.”
2 Corinthians 5:8
“Mas confiamos, y más quisiéramos partir del cuerpo, y estar presentes al Señor.”
2 Corintios 5:8
For my father — who taught me, long before the equations did, that the deepest commitments are the irreversible ones, and that what is given in love endures past every threshold.